H2N2V1, Main, Exploration, bibRecord, 002201

Antigenic heterogeneity within influenza A(H3N2) virus strains*

Identifieur interne : 002201 ( Main/Exploration ); précédent : 002200; suivant : 002202

Antigenic heterogeneity within influenza A(H3N2) virus strains*

Auteurs : J. C. De Jong ; F. M. De Ronde-Verloop ; T. M. Veenendaal-Van Herk ; T. F. Weijers ; K. Bijlsma ; A. D. M. E. Osterhaus

Source :

Bulletin of the World Health Organization [ 0042-9686 ] ; 1988.

RBID : PMC:2491107

Abstract

On the basis of their antigenic properties, influenza virus strains are classified into types and subtypes, which are further subdivided into variants that differ to various degrees in haemagglutination-inhibition assays. Evidence is presented that during infection with an influenza A(H3N2) virus the respiratory tract of a human patient often harbours more than one antigenic virus variant. These variants are frequently propagated by embryonated fowl eggs and monkey cells with different efficiencies, and this may lead to the selection of different variants by either of these host systems. Also, passage of virus by a given host is sometimes attended by changes in reactivity in haemagglutination-inhibition tests. In some cases the heterogeneity described also affects the specific immunogenicity of the virus in ferrets. Virus strains cloned in monkey kidney cell cultures gave variants that were stable upon further passage. These results may have implications for antigenic and biochemical investigations of epidemiologically relevant virus variants. It is argued that the antigenic drift of influenza A(H3N2) viruses is best characterized by analyses, both with post-infection ferret antisera and with panels of monoclonal antibodies, of virus strains isolated and passaged in monkey kidney cell cultures only.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2491107

PubMed: 3260141
PubMed Central: 2491107

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antigenic heterogeneity within influenza A(H3N2) virus strains<xref ref-type="fn" rid="fn1">*</xref>
</title>
<author><name sortKey="De Jong, J C" sort="De Jong, J C" uniqKey="De Jong J" first="J. C." last="De Jong">J. C. De Jong</name>
</author>
<author><name sortKey="De Ronde Verloop, F M" sort="De Ronde Verloop, F M" uniqKey="De Ronde Verloop F" first="F. M." last="De Ronde-Verloop">F. M. De Ronde-Verloop</name>
</author>
<author><name sortKey="Veenendaal Van Herk, T M" sort="Veenendaal Van Herk, T M" uniqKey="Veenendaal Van Herk T" first="T. M." last="Veenendaal-Van Herk">T. M. Veenendaal-Van Herk</name>
</author>
<author><name sortKey="Weijers, T F" sort="Weijers, T F" uniqKey="Weijers T" first="T. F." last="Weijers">T. F. Weijers</name>
</author>
<author><name sortKey="Bijlsma, K" sort="Bijlsma, K" uniqKey="Bijlsma K" first="K." last="Bijlsma">K. Bijlsma</name>
</author>
<author><name sortKey="Osterhaus, A D M E" sort="Osterhaus, A D M E" uniqKey="Osterhaus A" first="A. D. M. E." last="Osterhaus">A. D. M. E. Osterhaus</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">3260141</idno>
<idno type="pmc">2491107</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2491107</idno>
<idno type="RBID">PMC:2491107</idno>
<date when="1988">1988</date>
<idno type="wicri:Area/Pmc/Corpus">000281</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000281</idno>
<idno type="wicri:Area/Pmc/Curation">000281</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000281</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000D33</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000D33</idno>
<idno type="wicri:Area/Ncbi/Merge">001058</idno>
<idno type="wicri:Area/Ncbi/Curation">001058</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001058</idno>
<idno type="wicri:doubleKey">0042-9686:1988:De Jong J:antigenic:heterogeneity:within</idno>
<idno type="wicri:Area/Main/Merge">002309</idno>
<idno type="wicri:Area/Main/Curation">002201</idno>
<idno type="wicri:Area/Main/Exploration">002201</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Antigenic heterogeneity within influenza A(H3N2) virus strains<xref ref-type="fn" rid="fn1">*</xref>
</title>
<author><name sortKey="De Jong, J C" sort="De Jong, J C" uniqKey="De Jong J" first="J. C." last="De Jong">J. C. De Jong</name>
</author>
<author><name sortKey="De Ronde Verloop, F M" sort="De Ronde Verloop, F M" uniqKey="De Ronde Verloop F" first="F. M." last="De Ronde-Verloop">F. M. De Ronde-Verloop</name>
</author>
<author><name sortKey="Veenendaal Van Herk, T M" sort="Veenendaal Van Herk, T M" uniqKey="Veenendaal Van Herk T" first="T. M." last="Veenendaal-Van Herk">T. M. Veenendaal-Van Herk</name>
</author>
<author><name sortKey="Weijers, T F" sort="Weijers, T F" uniqKey="Weijers T" first="T. F." last="Weijers">T. F. Weijers</name>
</author>
<author><name sortKey="Bijlsma, K" sort="Bijlsma, K" uniqKey="Bijlsma K" first="K." last="Bijlsma">K. Bijlsma</name>
</author>
<author><name sortKey="Osterhaus, A D M E" sort="Osterhaus, A D M E" uniqKey="Osterhaus A" first="A. D. M. E." last="Osterhaus">A. D. M. E. Osterhaus</name>
</author>
</analytic>
<series><title level="j">Bulletin of the World Health Organization</title>
<idno type="ISSN">0042-9686</idno>
<imprint><date when="1988">1988</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>On the basis of their antigenic properties, influenza virus strains are classified into types and subtypes, which are further subdivided into variants that differ to various degrees in haemagglutination-inhibition assays. Evidence is presented that during infection with an influenza A(H3N2) virus the respiratory tract of a human patient often harbours more than one antigenic virus variant. These variants are frequently propagated by embryonated fowl eggs and monkey cells with different efficiencies, and this may lead to the selection of different variants by either of these host systems. Also, passage of virus by a given host is sometimes attended by changes in reactivity in haemagglutination-inhibition tests. In some cases the heterogeneity described also affects the specific immunogenicity of the virus in ferrets. Virus strains cloned in monkey kidney cell cultures gave variants that were stable upon further passage. These results may have implications for antigenic and biochemical investigations of epidemiologically relevant virus variants. It is argued that the antigenic drift of influenza A(H3N2) viruses is best characterized by analyses, both with post-infection ferret antisera and with panels of monoclonal antibodies, of virus strains isolated and passaged in monkey kidney cell cultures only.</p>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Bijlsma, K" sort="Bijlsma, K" uniqKey="Bijlsma K" first="K." last="Bijlsma">K. Bijlsma</name>
<name sortKey="De Jong, J C" sort="De Jong, J C" uniqKey="De Jong J" first="J. C." last="De Jong">J. C. De Jong</name>
<name sortKey="De Ronde Verloop, F M" sort="De Ronde Verloop, F M" uniqKey="De Ronde Verloop F" first="F. M." last="De Ronde-Verloop">F. M. De Ronde-Verloop</name>
<name sortKey="Osterhaus, A D M E" sort="Osterhaus, A D M E" uniqKey="Osterhaus A" first="A. D. M. E." last="Osterhaus">A. D. M. E. Osterhaus</name>
<name sortKey="Veenendaal Van Herk, T M" sort="Veenendaal Van Herk, T M" uniqKey="Veenendaal Van Herk T" first="T. M." last="Veenendaal-Van Herk">T. M. Veenendaal-Van Herk</name>
<name sortKey="Weijers, T F" sort="Weijers, T F" uniqKey="Weijers T" first="T. F." last="Weijers">T. F. Weijers</name>
</noCountry>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002201 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002201 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    H2N2V1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:2491107
   |texte=   Antigenic heterogeneity within influenza A(H3N2) virus strains*
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:3260141" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a H2N2V1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 14 19:59:40 2020. Site generation: Thu Mar 25 15:38:26 2021

Serveur d'exploration H2N2

Antigenic heterogeneity within influenza A(H3N2) virus strains*

Antigenic heterogeneity within influenza A(H3N2) virus strains*

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration H2N2
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.